New Dosing on Extra Strength Tylenol®, an Acetaminophen Containing Product

McNeil, the makers of Tylenol®, states that over 600 medications, both over-the-counter and prescription, contain acetaminophen, the active ingredient in Tylenol®.

Beginning in Fall 2011, McNeil will be introducing new dosing instructions on their single-ingredient Extra Strength Tylenol®. These are the revised dosing instructions that will be on OTC Extra Strength Tylenol® label.

Directions: Take 1-2 caplet(s) (1000 mg) every 6 hours while symptoms last;
(as opposed to 1-2 caplet(s) every 4-6 hours)

Not to Exceed more than 6 caplets (3000 mg) in 24 hours, unless directed by a doctor.
(as opposed to 8 caplet(s) in 24 hours)

"For patients whose pain or fever recurs despite the administration of a total daily dose of 3000 mg, as noted, above, the new dosing instructions allow for heatlhcare professionals to exercise their discretion. The liver warning on the OTC label will continue to state that severe liver damage may occur if more than 4000 mg of acetaminophen is taken. The warnings section will be modified to reflect the new daily dose. (McNeil)"

McNeil states that they will be lowering the dosing instructions for their Regular Strength Tylenol® beginning in 2012.

REMEMBER: Many medications utilize acetaminophen as an active ingredient; check to see what you may be taking for your symptoms, it may contain acetaminophen.  Check with your primary care physician if you are taking multiple sources of acetaminophen, and verify that you are taking a safe dosage.



Jeremy KW Spiewak, CPhT, MA RPhT, BA Chemistry, Doctor of Pharmacy Candidate at Massachusetts College of Pharmacy and Health Sciences

Edited By:

Linda C. Rock, RPh, MS and BS Pharmacy Northeastern University

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Kuffner, Edwin K. VP OTC Medical Affairs and Clinical Research. McNeil Consumer Healthcare Division 2011

Tylenol. Drug Facts and Comparisons® eAnswers [online]. 2010. Available through Wolters Kluwer Health, Inc. Accessed August 10, 2010

Additional Resources:

If you have any questions McNeil has made their Medical Affairs Department available at 1 (866) 948-6883 Monday-Friday 9:00am to 4:30pm EST

Original Published:August 2010

Revised:August 2010